We analyse not just direct healthcare costs, but also education, employment, and social impacts, providing a true societal perspective. We assess whether interventions meet the needs of vulnerable groups, including those with low socio-economic status, migrant backgrounds, disabilities, or LGBTQ+ identities. Our HTA models are adapted to different European healthcare systems: from strong primary care models to mixed financing structures and thus ensuring real-world applicability. Young people, clinicians, policymakers, and HTA specialists co-create the outcome measures, making sure our assessments reflect what really matters in practice.